An Elevated high-sensitive C-Reactive Protein (hsCRP)

Dr. Peter King, MD, FACC, FACP, FCCP, FICA
Consultant Cardiologist

In your health assessment at GHC, you often receive a report of hsCRP measurement. The CRP level is thought to be a biomarker of inflammation, and now hsCRP has been associated with an increased risk of myocardial infarction, stroke and peripheral arterial disease.

hsCRP <===> Risk for Cardiovascular Disease
<1.0 mg/L==>Low
1.0-3.0 mg/L==>Intermediate
>3.0 mg/L==>High

In a recent published study – JUPITER, of almost 18,000 patients with an elevated hsCRP level and no heart disease or high blood pressure, the subgroup with no smoking, normal body weight, normal cholesterol and no metabolic syndrome, benefited from statin (a cholesterol-lowing drug) therapy with a 44% reduction in the incidence of heart attack, stroke or cardiovascular death.

The study results suggest lower LDL (bad) cholesterol levels are optimal, even in individuals with minimal risk factors and isolated elevated hsCRP. You should discuss with your doctor about further treatment if you have an elevated hsCRP.